Abstract

Background: It has been suggested that platelet count(PLT) and mean platelet volume(MPV) can be used as inflammation marker in tuberculosis and pneumonia. Aims and objectives: PLT and MPV in sarcoidosis were not investigated. Objective of this study was to determine whether PLT and MPV can be used as a differiantial marker betweeen sarcoidosis and tuberculosis which are granulomatous diseases and presenting with similar symptoms. Methods: We performed prospective study with 100 patients with sarcoidosis (group 1), 83 patients with tuberculosis (group 2), 63 patients with pmoumonia (group 3) and 36 healthy control individuals (group 4). In this study we compared to inflammatory markers, platelet count and MPV values of four groups. Results: WBC, ESR, CRP and PLT values were lower in control group. Between sarcoidosis , tuberculosis and pnoumonia group, these values were significantly lower in sarcodosis group.MPV values was found significantly lower in tuberculosis group. PLT values of tuberculosis group was found significantly higher compared to sarcoidosis group (p<0.001). MPV values of tuberculosis group was found significantly lower than sarcoidosis group (p<0.001) Conclusion: It has been suggested that, the abnormalities of PLT and MPV associated with inflammatory reaction, not groulomatous reaction so thrombocytosis and low MPV can be used for differiantion of tuberculosis from sarcoidosis but we need further studies.

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