Medical Hypotheses | VOL. 166
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Can plant-derived anti-HIV compounds be used in COVID-19 cases?

Publication Date Sep 1, 2022

Abstract

People living with HIV are more exposed to the adverse health effects of the worldwide COVID-19 pandemic. The pandemic's health and social repercussions may promote drug abuse and inadequate HIV management among this demographic. The coronavirus pandemic of 2019 (COVID-19) has caused unprecedented disruption worldwide in people's lives and health care. When the COVID-19 epidemic was identified, people with HIV faced significant obstacles and hurdles to achieving optimal care results. The viral spike protein (S-Protein) and the cognate host cell receptor angiotensin-converting enzyme 2 (ACE2) are both realistic and appropriate intervention targets. Calanolides A, Holy Basil, Kuwanon-L, and Patentiflorin have anti-HIV effects. Our computational biology study investigated that these compounds all had interaction binding scores related to S protein of coronavirus of -9.0kcal /mol, -7.1kcal /mol, -9.1kcal /mol, and -10.3kcal/mol/mol, respectively. A combination of plant-derived anti-HIV compounds like protease inhibitors and nucleoside analogs, which are commonly used to treat HIV infection, might be explored in clinical trials for the treatment of COVID-19.

Concepts

Promote Drug Abuse Viral Spike Protein People's Health Care anti-HIV Effects Holy Basil Social Repercussions Plant-derived Compounds Angiotensin-converting Enzyme 2 People's Health Nucleoside Analogs

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