Can physician gestalt predict survival in patients with resectable pancreatic adenocarcinoma?

Abstract

Clinician gestalt may hold unexplored information that can be capitalized upon to improve existing nomograms. The study objective was to evaluate physician ability to predict 2-year overall survival (OS) in resected pancreatic ductal adenocarcinoma (PDAC) patients based on pre-operative clinical characteristics and routine CT imaging. Ten surgeons and two radiologists were provided with a clinical vignette (including age, gender, presenting symptoms, and pre-operative CA19-9 when available) and pre-operative CT scan for 20 resected PDAC patients and asked to predict the probability of each patient reaching 2-year OS. Receiver operating characteristic curves were used to assess agreement and to compare performance with an established institutional nomogram. Ten surgeons and 2 radiologists participated in this study. The area under the curve (AUC) for all physicians was 0.707 (95% CI 0.642-0.772). Attending physicians with>5years experience performed better than physicians with<5years of clinical experience since completion of post-graduate training (AUC=0.710, 95% CI [0.536-0.884] compared to AUC=0.662, 95% CI [0.398-0.927]). Radiologists performed better than surgeons (AUC=0.875, 95% CI [0.765-0.985] compared to AUC=0.656, 95% CI [0.580-0.732]). All but one physician outperformed the clinical nomogram (AUC=0.604). This pilot study demonstrated significant promise in the quantification of physician gestalt. While PDAC remains a difficult disease to prognosticate, physicians, particularly those with more clinical experience and radiologic expertise, are able to perform with higher accuracy than existing nomograms in predicting 2-year survival.