Abstract
The oocyte from the South African clawed frog Xenopus laevis is a versatile expression system particularly suitable for the study of membrane transporters and channels. Due to minimal background activity and very high signal-to-noise ratios, oocytes are often used to evaluate the function, structure and signal transduction pathways of a variety of different proteins. One such group of proteins are the water channels, or aquaporins. Of particular note, studies in Xenopus oocytes have contributed to our understanding of an inherited form of nephrogenic diabetes insipidus. However, as highlighted by Leduc-Nadeau et al. (2010) in a recent issue of The Journal of Physiology, caution should be taken in interpreting the results of studies on membrane proteins in Xenopus oocytes.
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