Abstract
Background: Exercise is the cornerstone of conservative management for persistent pain. While exercise is effective in the treatment of persistent pain, systematic reviews demonstrate, at best, small to moderate effects on pain. Thus, novel approaches that could enhance the hypoalgesic effects of exercise are warranted. Transcranial direct current stimulation (tDCS), a safe, painless non-invasive brain stimulation technique is capable of modulating pain processing and provides a promising avenue to boost the hypoalgesic response to exercise. Here, we explored whether the application of tDCS prior to a single bout of exercise would facilitate exercise-induced hypoalgesia in healthy individual's experiencing persistent experimental muscle pain.
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