Abstract
The new technological advances in radiation therapy (e.g., proton therapy and FLASH radiotherapy) have indicated high therapeutic effects in all cancer types. Recently, several scientific projects have been conducted for factors that can influence treatment responses in radiation oncology. Nocturnal sleep has effective healing properties, which are involved in the regulation of physical and biochemical factors. It could significantly increase the level of hormones, radical scavengers, and cytokines such as glutathione, melatonin, and interleukin-12. Many papers have been published about the role of sleep deprivation in diseases, but there is no scientific publication regarding the link between nocturnal sleep and radiation therapy. In the current paper, the links between nocturnal sleep, the immune system, and radiation therapy were evaluated to provide clear and understandable explanations for the hypothesis that nocturnal sleep after radiation therapy could improve treatment efficiency.
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