Abstract
Can microcalcifications' characteristics predict the risk of breast cancer metastasis to bone?
Highlights
Bone metastasis from breast cancer represent the main disability associated to breast cancer[1,2]
Based on the presence of metastatic lesions at 5 years from diagnosis, biopsies collected in the study were classified as follow: 30 infiltrating carcinomas of patients with clinical evidence of bone metastasis (BM+) (59.65 ± 1.23 years) and 40 infiltrating carcinomas of patients without clinical evidence of bone metastasis (BM-) (57.91 ± 0.96 years)
Microcalcifications were detectable in 63.3% of BM+ and in 62.5% of BM
Summary
Bone metastasis from breast cancer represent the main disability associated to breast cancer[1,2]. Studies of Scimeca et al.[7] highlighted the essential role of PTX3 in bone metabolisms founding a correlation between the impairment of PTX3 expression and the inhibition of osteoblast activity. In these reports authors suggested a direct role of PTX3 in the assembly of HA crystals. The presence of BOLCs into breast cancer lesions is associated to the development of bone metastatic lesions at five years from diagnosis.
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