Abstract
The toxic reactive aldehyde 4-hydroxynonenal (4-HNE) belongs to the advanced lipid peroxidation end products. Accumulation of 4-HNE and formation of 4-HNE adducts induced by redox imbalance participate in several cytotoxic processes, which contribute to the pathogenesis and progression of oxidative stress-related human disorders. Medicinal plants and bioactive natural compounds are suggested to be attractive sources of potential agents to mitigate oxidative stress, but little is known about the therapeutic potentials especially on combating 4-HNE-induced deleterious effects. Of note, some investigations clarify the attenuation of medicinal plants and bioactive compounds on 4-HNE-induced disturbances, but strong evidence is needed that these plants and compounds serve as potent agents in the prevention and treatment of disorders driven by 4-HNE. Therefore, this review highlights the pharmacological basis of these medicinal plants and bioactive compounds to combat 4-HNE-induced deleterious effects in oxidative stress-related disorders, such as neurotoxicity and neurological disorder, eye damage, cardiovascular injury, liver injury, and energy metabolism disorder. In addition, this review briefly discusses with special attention to the strategies for developing potential therapies by future applications of these medicinal plants and bioactive compounds, which will help biological and pharmacological scientists to explore the new vistas of medicinal plants in combating 4-HNE-induced deleterious effects.
Highlights
The toxic reactive aldehyde 4-hydroxynonenal (4-HNE) belongs to the advanced lipid peroxidation end products [1]
Quercetin improves cell membrane integrity and mitochondrial function and decreases IL-6, IL-8, and monocyte chemotactic protein 1 (MCP-1) production, presumably by regulating mitogen-activated protein kinase (MAPK)/NF-κB signaling pathway in ARPE-19 cells stimulated by inflammatory cytokine [65]
Nectarine ameliorates aging-related death and reduces oxidative damage in female sod1-mutant flies [129]. These results demonstrate that the attenuation of 4-HNE-induced energy metabolism disorders by medicinal plants and bioactive compounds may promote longevity
Summary
The toxic reactive aldehyde 4-hydroxynonenal (4-HNE) belongs to the advanced lipid peroxidation end products [1]. Medicinal plants have been widely used to prevent and treat various kinds of disorders for thousands of years Their extracts and bioactive compounds have the ability to prevent the cells from oxidative stress injury [9,10,11]. This review aims to highlight the pharmacological basis of medicinal plants and bioactive compounds in the attenuation of 4-HNE-induced deleterious effects, as well as the underlying molecular mechanisms. This review briefly discusses the strategies for developing potential therapies in future applications of these medicinal plants and compounds, which will benefit biological and pharmacological scientists to explore the new vistas of medicinal plants in combating 4-HNE-induced deleterious effects
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