Can mean platelet volume predicts renal outcome in acute on chronic kidney disease?

Abstract

This study aimed to investigate the role of mean platelet volume (MPV) in predicting renal outcome in acute kidney injury (AKI) developing on pre-existing chronic kidney disease (CKD). The patients whose first hemodialysis program was initiated in our center were divided into two groups as those who were taken to the scheduled dialysis program after discharge and those who were not dialysis-dependent. Groups were compared in terms of demographic characteristics, and laboratory parameters including MPV. A total of 288 patients were included in the study (scheduled dialysis=162 patients, nondialysis dependent=126 patients). High MPV was found to be an independent risk factor for scheduled dialysis programs in multivariable analyses (OR [95% CI]: 90.9 [6.3-1313.6], p: 0.001). CKD patients with high MPV were more likely to be included in scheduled dialysis programs after an AKI attack. MPV is found to be an independent risk factor and a reliable predictor for a scheduled dialysis program.