Abstract
Amir et al. compared concentration and injection pain of benzathine penicillin G between two diluents, either sterile water or lidocaine hydrochloride 1%. Theyfound that although lidocaine significantly reduced injection pain, it did not change penicillin concentration 3in body fluids. Patel et al. investigated the effect of lidocaine 1% as a diluent Lidocaine as a diluent for ceftriaxone in the treatment of gonorrhea. Does it on the pharmacokinetics and tolerance of IM ceftriaxone and showed that lidocaine neither changed parameters nor altered its bioavailability. In addition, pain intensity and frequency at the injection site were reduced considerably by administering lidocaine.
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