Abstract
BackgroundPerthes disease (Legg-Calvé-Perthes, LCP) is a self-limited and non-systemic disease occurring in the femoral heads of children, which is mainly manifested as an ischemic necrosis of the femoral head epiphysis, leading to subchondral ossification injury of the femoral head.Case presentationHere we report a case of 11-year-old child with long-term use of high-dose glucocorticoids. With MRI examination finding the epiphyseal necrosis of right humeral head, femur and tibia, and X-ray examination finding bilateral femoral head necrosis, the child was diagnosed as Perthes disease based on his clinical and imaging data.ConclusionsLong-term and high-dose glucocorticoids may be one of the causes of Perthes disease.
Highlights
Necrosis of the femoral head in children, known as Perthes disease (Legg-Calvé-Perthes, LCP), is a selflimited and non-systemic disease occurring in the femoral heads of children, which is mainly manifested as an ischemic necrosis of the femoral osteoepiphysis leading to subchondral ossification injury of the femoral head [1]
Long-term use of glucocorticoids in large doses is associated with necrosis of the femoral head in adults [45,46,47], which is the most common and important risk factor that results in 10-30 % of necrosis of the femoral head in adults [48]
This paper presents a case of the association between necrosis of the femoral head in children and the use of glucocorticoids, which would provide a new possibility for the causes of Perthes disease, so as to supplement the etiology and pathophysiology of this disease
Summary
Necrosis of the femoral head in children, known as Perthes disease (Legg-Calvé-Perthes, LCP), is a selflimited and non-systemic disease occurring in the femoral heads of children, which is mainly manifested as an ischemic necrosis of the femoral osteoepiphysis leading to subchondral ossification injury of the femoral head [1]. This paper presents a case of the association between necrosis of the femoral head in children and the use of glucocorticoids, which would provide a new possibility for the causes of Perthes disease, so as to supplement the etiology and pathophysiology of this disease.
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