Can inhaled insulin be used for the treatment of diabetes mellitus?

Abstract

Reluctance to start and adequately titrate subcutaneous insulin are major reasons why many patients with diabetes mellitus are insufficiently metabolically controlled. Pulmonary insulin administration has the advantage over subcutaneous insulin in that it is noninvasive, seems better accepted by the diabetic population and exerts equal efficacy in terms of glycemic control. As such, inhaled insulin has the potential to increase the diabetic (Type 2) patient’s willingness to commence and adhere to insulin therapy. Inhaled insulin’s short duration of action makes it suitable for prandial administration provided that basal insulin requirements are met by residual b-cell function, or by supplemental long-acting subcutaneous insulin. In clinical trials, inhaled insulin is comparable to short-acting subcutaneous insulin with regard to efficacy and hypoglycemic risk. Adverse effects associated with inhaled insulin include dry cough, which tends to diminish over time, a slight drop in pulmonary function that does not progress and is reversible in most patients if treatment is discontinued, and increased insulin antibody formation, albeit without clinical sequelae. Long-term safety remains an issue for a product intended to be used chronically for many years. Exubera® was thus far the only inhaled insulin product to receive approval in the USA and Europe for use in adults with Type 1 or Type 2 diabetes, but was recently withdrawn from the market. At present it is unclear how this decision will affect programs from other companies with inhaled insulin products under development.