Abstract
Background & Aim Both chemokine receptor CXCR4 antagonist plerixafor (P) as well as high volume (HV) leukapheresis have been shown to reduce mobilization failure rates. However, no direct comparisons of such collection methods currently exist. In this single center retrospective study, we compared the collection efficiency in adult patients diagnosed with multiple myeloma (MM) or non-Hodgkins Lymphoma (NHL) undergoing autologous stem cell transplantation (ASCT) comparing yields based on pre apheresis peripheral blood (PB) CD34+ cell number ( 50 cells/µL, Fig 1). Methods, Results & Conclusion The collection methods used included HV vs. regular volume (RV) with or without P. There was a total of 116 patients (78 MM & 38 NHL) in the study group with a total of 191 collections. RV without P was used for patients whose pre-apheresis CD34 count was >50/µL. RV (+P) or HV (+P) or HV without P groups were used to investigate whether HV can substitute RV (+P) for poor mobilizers (
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