Can hemogram parameters be an indicator for the systemic effects of inhaled corticosteroids in COPD patients? A comparative review of different corticosteroids and different inhaler techniques.

Abstract

Background: While it is well known that systemic steroids may cause changes in hemogram parameters, it is important whether the use of inhaled corticosteroid (ICS) leads to changes in hemogram parameters. In this study, we aimed to find out the effects of ICSs on hemogram in comparison between different inhaler techniques of different corticosteroids. Methods: The medical records of 100 ICS user COPD patients and 100 ICS non-user COPD patients were reviewed retrospectively. Demographic data, complete blood count values, GOLD groups, history of pneumonia in the last year, content of bronchodilator treatments and valid inhaler techniques were recorded. Results: Significant increase was detected in the mean MCHC, Eosinophil%, #Eosinophil values among ICS non-users; and the mean RDW-CV, MCV, WBC, Neutrophil% and # Neutrophil values among ICS users (p