Abstract
As an introduction to this special issue on geroscience, the present work focuses on the complexity of disentangling biomolecular mechanisms of aging from biopsychosocial causes of accelerated aging. Due to this complexity, the biomolecular aging hallmarks of frailty and multimorbidity as predominant aging phenotypes in geriatrics reflect single aspects of the aging process. Apossible approach to facilitate the integration of geroscience into healthcare might be to consider aging as the dynamic ratio between damage accumulation at the molecular and cellular level and resilience as strategies that prevent or repair such damage. There is alarge body of evidence to show that geroscience has the potential to change healthcare; however, reaching aconsensus and translating the best tool to measure aging needs more research on 1)the sensitivity of biomarkers to interventions and 2)the relationship between changes in biomarkers and changes in health trajectories.
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