Abstract
AbstractBackgroundMany authors have explored the intriguing possibility that the regular intake of Allium sativum (garlic) might reduce cancer risk. Most of this evidence is based on epidemiological data which, by its very nature, may not be fully convincing in establishing causality.ObjectiveTo critically evaluate the evidence of effectiveness of garlic extract for reducing cancer risk.MethodsFive electronic databases and the authors' own departmental files were searched for relevant studies. Randomised controlled trials (RCTs) were included if they tested the effectiveness of garlic extracts or garlic compounds on cancer risk or related variables. The quality of included trials was determined using the Jadad score.ResultsFour eligible RCTs were identified. The quality of studies was mixed. The findings from these trials were not uniformly positive.ConclusionsEvidence from RCTs lends little support to the notion that garlic reduces the risk of cancer.
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