Abstract
Evidence is examined relative to the possibility that feline oncornaviruses can play a role in the induction of some lymphoreticular neoplasms in man, and a hypothesis is presented to suggest how this can occur. Points that implicate the feline oncornaviruses in this way are: (1) many domestic cats in their natural environment excrete FeLV; (2) feline oncornaviruses will induce tumors in several species, including subhuman primates; (3) field strains of FeLV will replicate in human cells; (4) FSV will transform human cells; (5) immunologic depression can greatly interfere with in vivo virus neutralization; (6) immunologic depression greatly enhances the development of spontaneous lymphoreticular neoplasms and those induced in animals with oncornaviruses, and (7) children represent the age group most likely to be exposed to FeLV and to undergo temporary periods of immune depression due to exposure to the common childhood viral diseases and viral vaccines.
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