Can Doppler echocardiography estimate raised pulmonary capillary wedge pressure provoked by passive leg lifting in suspected heart failure?

Abstract

Non-invasive estimation of left ventricular filling pressure (LVFP) during stress is important for explaining exertional symptoms in patients with heart failure (HF). The aim of this study was to evaluate ability of Doppler echocardiographic measures of elevated LVFP with passive leg lifting (PLL) in patients with suspected HF. Twenty-nine patients with clinical signs of HF who underwent simultaneous Doppler echocardiography and right heart catheterization (RHC) at rest and during PLL were consecutively investigated. Seventeen patients had normal PCWP (≤15mmHg) at rest and during PLL and 12 with normal PCWP at rest but >15mmHg with PLL. Conventional echo and 2D strain were used to assess early diastolic blood flow velocity (E), LV strain rate during early diastole (LVSRe), left atrial SR during atrial contraction (LASRa) and myocardial tissue Doppler velocities to assess lateral e' and further calculate E/e' and E/LVSRe and their relationship with PCWP, at rest and during PLL. Resting LAVI (β=0·45, P=0·009) and LASRa (β=-0·51, P=0·004) were independently related to PCWP during PLL. Also, LASRa (β=-0·77, P<0·001), E/e' (β=0·40, P=0·04) and E/LVSRe (β=0·47, P=0·021) during PLL correlated with PCWP during PLL. Multiple regression analysis identified E/LVSRe (β=0·46, P=0·001) and LASRa (β=-0·58, P=0·002) during PLL as being independently associated with PCWP during PLL. Left atrial volume and myocardial contraction (LASRa) at rest both predict unstable LV filling pressures measured as raised PCWP when provoked by PLL. Furthermore, LASRa at PLL seems to have the strongest association to PCWP during PLL.