Abstract
Background and Purpose: The aim is to determine the effect of the communication skills training (CST) using interactive synchronous and asynchronous methods, which was applied for the first time on medical students’ empathy levels.
 Methods: This study is a cross-sectional-analytical, self-controlled intervention. 
 The distance CST program was applied to first-year medical students. The change in students’ empathy levels was measured with the student version of the Jefferson Empathy Scale.
 Results: 241 students’ forms were included. Empathy mean score increased significantly, this increase was higher in women.
 Conclusion: The distance CST produced a positive effect on empathy levels. While interactive
 PowerPoint® presentations, videos, movie clips, cartoons, real-life examples, written/audio question-
 answer activities, surveys, feedback and, small group work were used in live lessons; in the
 asynchronous process, student-based techniques (self-assessment, homework, WhatsApp® sharing)
 were used to support the online learning climate. We believe that all of them support the cognitive and
 social existence of students throughout the training. We propose our program as a model that can be
 used during situations where face-to-face education is not possible and to support face-to-face
 education in medical education.
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