Abstract
Astemizole and terfenadine were the prototypic nonsedating antihistamines, but they have the potential to cause cardiac arrhythmias by interfering with cardiac potassium channels and prolonging the QT interval. The risk is heightened because the levels of these drugs increase in the presence of inhibitors of cytochrome P450 3A4 (CYP3A4). Recently, diphenhydramine (DPH) (Benadryl and others), the prototypic H1-receptor antagonist, has been found to …
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