Abstract
Purpose: Questionnaires assessing patients’ pain level represent the majority of efficacy endpoints in osteoarthritis (OA) randomized clinical trials (RCTs). The intrinsic subjectivity of pain may render the evaluation of these questionnaires difficult. In turn, this could explain the high variability observed in the treatment response in OA RCTs. Mitigation of the the evaluation error could therefore help to increase the quality of study data.
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