Abstract
first_page settings Order Article Reprints Font Type: Arial Georgia Verdana Font Size: Aa Aa Aa Line Spacing: Column Width: Background: Open AccessConference Report Can Collapse Freeze Drying Provide High Density Protein Sugar Particles for Ballistic Powder Injection? by E. E. KIS, G. WINTER and J. MYSCHIK * Department of Pharmacy, Ludwig-Maximilians-University, Munich, Germany * Author to whom correspondence should be addressed. Sci. Pharm. 2010, 78(3), 653; https://doi.org/10.3797/scipharm.cespt.8.PMS26 Received: 12 July 2010 / Accepted: 12 July 2010 / Published: 12 July 2010 Download Download PDF Versions Notes Abstract Ballistic powder injection is an emerging needle-free technology. [...] Share and Cite MDPI and ACS Style KIS, E.E.; WINTER, G.; MYSCHIK, J. Can Collapse Freeze Drying Provide High Density Protein Sugar Particles for Ballistic Powder Injection? Sci. Pharm. 2010, 78, 653. https://doi.org/10.3797/scipharm.cespt.8.PMS26 AMA Style KIS EE, WINTER G, MYSCHIK J. Can Collapse Freeze Drying Provide High Density Protein Sugar Particles for Ballistic Powder Injection? Scientia Pharmaceutica. 2010; 78(3):653. https://doi.org/10.3797/scipharm.cespt.8.PMS26 Chicago/Turabian Style KIS, E. E., G. WINTER, and J. MYSCHIK. 2010. "Can Collapse Freeze Drying Provide High Density Protein Sugar Particles for Ballistic Powder Injection?" Scientia Pharmaceutica 78, no. 3: 653. https://doi.org/10.3797/scipharm.cespt.8.PMS26 Find Other Styles Article Metrics No No Article Access Statistics For more information on the journal statistics, click here. Multiple requests from the same IP address are counted as one view.
Highlights
Ballistic powder injection is an emerging needle-free technology
A polymer like dextran is vital for the partial collapse of the spray freeze dried particles, but it is responsible for the reduced stabilizing effect on the protein [2]
Our approach is to apply an aggressive freeze drying cycle as performed by Schersch et al to evoke a collapse of the sugar matrix and generate a high density structure of the freeze dried cake [3]
Summary
Ballistic powder injection is an emerging needle-free technology. Powder particles are accelerated towards the skin and penetrate the superficial layers. Ballistic powder injection is an emerging needle-free technology. Powder particles are accelerated towards the skin and penetrate the superficial layers.
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