Abstract
A wealth of research has investigated the aging brain using blood oxygenation level dependent functional MRI [Blood oxygen level dependent (BOLD) functional magnetic resonance imaging (fMRI)]. However, many studies do not consider the aging of the cerebrovascular system, which can influence the BOLD signal independently from neural activity, limiting what can be inferred when comparing age groups. Here, we discuss the ways in which the aging neurovascular system can impact BOLD fMRI, the consequences for age-group comparisons and possible strategies for mitigation. While BOLD fMRI is a valuable tool in this context, this review highlights the importance of consideration of vascular confounds.
Highlights
With an expanding older population, research into the aging brain has become increasingly important
The Blood oxygen level dependent (BOLD) signal reflects the balance between changes in cerebral blood flow (CBF), determined by the characteristics of neurovascular coupling (NVC), and changes in tissue oxygen consumption
This provides strong evidence for an age-related decrease in Cerebrovascular Reactivity (CVR); this would lead to a smaller amount of vasodilation and subsequent evoked CBF, deoxyhaemoglobin, and BOLD signal, causing an under-representation of neural responses in older groups when comparing across ages
Summary
Resonance Imaging Be Used Accurately to Compare Older and Younger Populations? A wealth of research has investigated the aging brain using blood oxygenation level dependent functional MRI [Blood oxygen level dependent (BOLD) functional magnetic resonance imaging (fMRI)]. Many studies do not consider the aging of the cerebrovascular system, which can influence the BOLD signal independently from neural activity, limiting what can be inferred when comparing age groups. We discuss the ways in which the aging neurovascular system can impact BOLD fMRI, the consequences for age-group comparisons and possible strategies for mitigation. While BOLD fMRI is a valuable tool in this context, this review highlights the importance of consideration of vascular confounds
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