Can Au/Ag/Fe nanoparticle composition restore blood cell counts in terms of DMH-induced colon adenocarcinoma?

Abstract

Scientific interest in nanomedicine nowadays is constantly growing, and nanomaterials have found wide application in diagnosis and treatment of various diseases. The most promising seem to be metal nanoparticles (NP). Some of them are actively studied in separate and there are favorable results considering their ability to normalize blood cell counts, but their co-work as a composite is still not well known. This opens a great perspective for studying NP as the blood homeostasis corrector, which could help in developing treatment schemes for many threatening diseases followed by the blood cell count disorders, especially malignant tumors. As colorectal cancer is third most commonly diagnosed, this study was focused on evaluation of blood cell counts changes in rats with DMH-induced colon adenocarcinoma in situ along with the assessment of Au/Ag/Fe NP composition corrective effect. Colon adenocarcinoma was induced by introducing N,N-dimethylhydrazine hydrochloride during 30 weeks. After pathohistological verification of developing colon adenocarcinoma in situ in DMH-treated rats Au/Ag/Fe NP composition was administered during 3 weeks. Introducing NP to the DMH-injured rats lead to increasing RBC and HGB and decreasing pathologically high-leveled MCV, MCH and MCHC to normal references. Assessed NP composition normalized the neutrophils rate, LMR and gave us a PLT rate particularly the same, as in the control group animals. Taking into account the previously proven biosafety of gold, silver and iron NP on their own and as a result the predicted biosafety of their composition we can consider further amplification of preclinical study on this NP composition of high significance, as it might be possibly used as following therapy of non-metastatic forms of colon cancer.