Abstract
ImportancePrevious studies report both coexistence and mutual exclusivity of atopic eczema (AE) and psoriasis, but these have not been appraised systematically. Knowledge of such disease association throws light on disease mechanisms and may influence therapeutic choices.ObjectiveTo summarise evidence for AE and psoriasis occurring in the same person at the same point in time. Planned primary outcome was the incidence, prevalence or risk of psoriasis or eczema.MethodsOvid MEDLINE and Ovid Embase were searched from inception to 1st February 2020. The search strategy was built around the key terms ‘atopic eczema’, ‘psoriasis’ and ‘co‐existence’. Observational studies (cohort, case‐control, cross‐sectional and case‐series) with a minimum of 10 consecutive patients were included. There were no restrictions on participants, geography or language. Studies were selected, data extracted and critically appraised by two independent reviewers. Data were extracted on the method of diagnosis: health professional (dermatologist, criteria, other), self‐reported, not specified. Study quality was assessed using validated Joanna Brigg's Institute critical appraisal tools. A random‐effects model was used to combine studies. The effect of study quality on the pooled estimate was investigated using stratification. Heterogeneity was explored by subgroup analysis.ResultsThis review included 31 studies and 20 523 individuals with psoriasis and 1 405 911 with AE. Eight studies reported the prevalence of AE in those with psoriasis and values ranged from 0.17% to 20%: the pooled prevalence was 2% (95% confidence interval [CI]: 1, 3). Seven studies reported the prevalence of psoriasis in those with AE and values ranged from 0.3% to 12.6%; the pooled prevalence was 2% (95% CI: 1, 3). Ten studies were assessed as low risk of bias. Geographical area, method of diagnosis, setting and whether the assessment of diagnosis was blinded, partly contributed to the heterogeneity.ConclusionsThis review provides some evidence for the coexistence of AE and psoriasis. Clinicians should be aware of coexistence at diagnosis, when selecting therapies and when reviewing poor response to treatment.
Highlights
Atopic eczema and psoriasis are both common chronic, inflammatory diseases affecting the skin, with large variations in their incidence and prevalence between countries.[1,2,3] The individual, societal and healthcare costs of both diseases are significant
The primary objective of this systematic review and meta‐analysis is to investigate the incidence, prevalence or risk of eczema and psoriasis occurring in the same individual at the same point in time
The pooled prevalence estimate of eczema in those with psoriasis at the same time point was 2% (Figure 2)
Summary
Atopic eczema ( known as atopic dermatitis or just eczema) and psoriasis are both common chronic, inflammatory diseases affecting the skin, with large variations in their incidence and prevalence between countries.[1,2,3] The individual, societal and healthcare costs of both diseases are significant. We intend that new summative data on the coexistence of eczema and psoriasis will give important clinical or population level insight into the immunopathogenesis of both diseases. These data may inform the development and choice of targeted biologic treatments and may challenge how we clinically categorise disease. The primary objective of this systematic review and meta‐analysis is to investigate the incidence, prevalence or risk of eczema and psoriasis occurring in the same individual at the same point in time
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