Can anticarbamylated protein antibodies be used to support the diagnosis of systemic lupus erythematosus?

Abstract

Aim: Autoantibody development plays an important role in the pathogenesis of systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). In this study, we aimed to determine the diagnostic value of anticarbamylated protein antibody (anti-CarP) antibody in SLE and RA patients and its relationship with disease prognosis. Material &method: Fifty-seven SLE patients (F/M 50/7; median age 40.9±13.7; median disease duration 2years) who met the 2012 SLICC SLE diagnostic criteria were included in the study. A total of46 RA patients selected according to the 2010 ACR/EULAR diagnostic criteria (F/M 38/8; median age 54.2±12.4; median disease duration 2years) were included. A total of30 healthy individuals were selected as the control group. The anti-CarP antibody was studied by using human anticarbamylated protein antibodyELISA Kit (SunRedBio, Shanghai, China). Results: Anti-CarP antibody positivity was found to be 17.4% in RA patients (p <0.001), 54.4% in SLE patients (p <0.001)and 3.3% in the healthy control group. The anti-CarP antibody was determined to predict SLE patients with 54.4% sensitivity and 96.7% specificity compared with the healthy control group (area under the curve: 0.755; p<0.001). Conclusion: Anti-CarP antibody positivity was significantly higher in the SLE patients compared with the healthy control and RA group. It has significant sensitivity and specificity in both SLE and RA patients compared with the healthy controls.