Can a hypercholesterolemic diet change the basal brain electrical activity and during status epilepticus in rats?

Abstract

The brain is an organ rich in lipids, including cholesterol, in which these lipids are associated to structure and brain function. Thus alterations in lipid levels of diets may interfere in the brain electrical activity. Our aim was to evaluate the interference of hypercholesterolemic diets in the brain electrical activity in normal individuals and with epilepsy. Histological analysis and electrocorticograms (ECoG) were performed in animals fed with and without hypercholesterolemic diet before and during the status epilepticus induced by pilocarpine. The power spectrum of ECoG was used to estimate the contribution of different brain rhythms in ECoG signal. The animals submitted to the status epilepticus showed cell death, vacuolization with destructuration of the cell layers. Both animal groups, those with status epilepticus and status epilepticus with hypercholesterolemic diet, showed cellular lesions similar. The hyperlipid diet promoted increase of brain electrical activity, this was revealed by increase in the average power of beta wave (14-30Hz) and decrease in the average power of the delta wave (0,5-4Hz). This increase of brain electrical activity was even higher when the animals were fed a hypercholesterolemic diet and submitted to status epilepticus. Animals fed with hypercholesterolemic diet and submitted to status epilepticus presented a higher increase in brain excitability compared to control animals. We observed that hypercholesterolemic diet favored a greater severity of the status epilepticus.