Abstract
Four-dimensional-CT ventilation imaging (CT-VI) is a novel method for imaging regional air volume changes in the lung. Previous attempts at comparing CT-VI and DTPA V-SPECT have shown poor results due to “clumping” of DTPA in large airways. Technegas is a smaller molecule than DTPA, and disperses throughout normal lung with less clumping and no washout. In this work we perform the first comparison of Technegas V-SPECT and CT-VI. We test the impact of two different CT ventilation metrics, and two different methods (algorithm- or clinician-based) for defining functional lung.
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