Abstract
We describe isolates from human Campylobacter infection in the French population and the isolates' antimicrobial drug resistance patterns since 1986 and compare the trends with those of isolates from broiler chickens and pigs from 1999 to 2004. Among 5,685 human Campylobacter isolates, 76.2% were C. jejuni, 17.2% C. coli, and 5.0% C. fetus. Resistance to nalidixic acid increased from 8.2% in 1990 to 26.3% in 2004 (p<10-3), and resistance to ampicillin was high over time. Nalidixic acid resistance was greater for C. coli (21.3%) than for C. jejuni (14.9%, p<10-3). C. jejuni resistance to ciprofloxacin in broilers decreased from 31.7% in 2002 to 9.0% in 2004 (p = 0.02). The patterns of resistance to quinolones and fluoroquinolones were similar between 1999 and 2004 in human and broiler isolates for C. jejuni. These results suggest a potential benefit of a regulation policy limiting use of antimicrobial drugs in food animals.
Highlights
Campylobacter infections are, along with Salmonella infections, the most common cause of bacterial diarrhea in humans worldwide [1,2,3,4,5,6]
Our surveillance of Campylobacter isolates in France indicates some differences with findings from other western countries, i.e., a greater proportion of C. coli (17.0%)
Campylobacter is predominant in the summer [27], the isolation rate was much greater in children
Summary
Campylobacter infections are, along with Salmonella infections, the most common cause of bacterial diarrhea in humans worldwide [1,2,3,4,5,6]. A recent study on illness and death due to foodborne infections in France estimated an isolation rate of 27–37/100,000 persons/year for Campylobacter infection [7]. Campylobacter are part of normal enteric flora in animals (poultry, pigs, and cattle) and can be transmitted to humans through contaminated foods [8]. Most Campylobacter enteric infections are self-limited and do not require antimicrobial drug treatment. In this article, we describe characteristics of human Campylobacter isolates in France and trends of antimicrobial resistance in such isolates from 1986 to 2004. Trends of Campylobacter antimicrobial drug resistance in human isolates were compared with those of isolates from broiler chickens and pigs between 1999 and 2004
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
