Abstract
Camphor sulfonic acid catalyzed a straightforward, efficient, and general method has been developed for the synthesis of 3,3'-(arylmethylene)bis(4-hydroxy-2H-chromen-2-ones), 3,3'-(arylmethylene)bis(2-hydroxynaphthalene-1,4-diones) and 3,3'-(2-oxoindoline-3,3-diyl)bis(2-hydroxynaphthalene-1,4-dione) derivatives in aqueous ethanol at room temperature from the reactions of various aromatic aldehydes and 4-hydroxycoumarin or 2-hydroxynaphthalene-1,4-dione respectively. Mild reaction conditions, use of metal-free organocatalyst, good to excellent yields, high atom-economy, environmentally benign, easy isolation of products, and no column chromatographic separation are some of the major benefits of this developed protocol.
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