Abstract
Direct three-component Mannich type reactions of (hetero)aromatic ketones with aromatic aldehydes and aromatic amines were efficiently catalyzed by camphor-10-sulfonic acid at ambient temperature under solvent free conditions to afford β-amino ketones in good to excellent yields. Syntheses of aminochromans were accomplished from one of the Mannich adducts via an unprecedented route involving intramolecular etherification with CuI/8-hydroxyquinoline.
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