Abstract
Purpose This study aimed to evaluate reports of patents for oral care formulations, based on Camellia sinensis (C. sinensis), deposited and granted in intellectual property banks. Methods A survey was conducted through collection, treatment, and analysis of extracted information from patent reports selected. The documentary research was conducted in January 2021 on formulations with C. sinensis for dental applications, including since the first patent deposits until the current time. The risk of bias of clinical trials with these formulations was analyzed to verify the scientific evidence. The data extracted represent the distribution of the number of patents by banks, annual evolution of patent deposits, applicant of patents by country, distribution of patents according to International Patent Classification codes, and the types of patented products. Results Data and information from 20 selected patents were extracted. The United States Patent and Trademark Office (USPTO) and World Intellectual Property Organization (WIPO) were the banks with the largest number of patents for products/formulations with C. sinensis for oral care applications with 7 (35%) and 6 (30%) patent registrations, respectively. Other banks did not provide patents related to the search. Patents of compositions were the largest with 14 filings, and the remainder of formulations are represented specially by mouthwashes and toothpastes. As for clinical application, 18 patents were filed as products with antimicrobial and antibiofilm action, while 2 patents are directed to the treatment of xerostomia. In general, the aspects of the studies of clinical efficacy pointed to a low risk of bias. Conclusion The study pointed out a small number of products protected by patents for Camellia sinensis for oral care indication, highlighting mainly mouthwash compositions and formulations. In the methodological parameters of clinical trials carried out with the formulations, the majority pointed out a low risk of bias.
Highlights
Lıdia Audrey Rocha Valadas,1,2 Rosueti Diogenes de Oliveira Filho,3 Edilson Martins Rodrigues Neto,2 Mary Anne Medeiros Bandeira,2 Marta Maria de França Fonteles,2 Vanara Florencio Passos,2 Ana Cristina de Mello Fiallos,2 Mara Assef Leitao Lotif,2 Nara Juliana Custodio de Sena,2 Thereza Cristina Farias Botelho Dantas,4,5 Igor Lima Soares,2 Patricia Leal Dantas Lobo,2 and Aldo Fabian Squassi 1
A survey was conducted through collection, treatment, and analysis of extracted information from patent reports selected. e documentary research was conducted in January 2021 on formulations with C. sinensis for dental applications, including since the first patent deposits until the current time. e risk of bias of clinical trials with these formulations was analyzed to verify the scientific evidence. e data extracted represent the distribution of the number of patents by banks, annual evolution of patent deposits, applicant of patents by country, distribution of patents according to International Patent Classification codes, and the types of patented products
Given the economic importance and medicinal products of C. sinensis, as well as its several benefits to systemic and mainly oral health, this study aimed to evaluate reports of patents deposited and granted on dental formulations based on C. sinensis in intellectual property banks
Summary
Lıdia Audrey Rocha Valadas ,1,2 Rosueti Diogenes de Oliveira Filho ,3 Edilson Martins Rodrigues Neto ,2 Mary Anne Medeiros Bandeira ,2 Marta Maria de França Fonteles ,2 Vanara Florencio Passos ,2 Ana Cristina de Mello Fiallos, Mara Assef Leitao Lotif ,2 Nara Juliana Custodio de Sena ,2 Thereza Cristina Farias Botelho Dantas ,4,5 Igor Lima Soares ,2 Patricia Leal Dantas Lobo ,2 and Aldo Fabian Squassi 1. Is study aimed to evaluate reports of patents for oral care formulations, based on Camellia sinensis (C. sinensis), deposited and granted in intellectual property banks. E data extracted represent the distribution of the number of patents by banks, annual evolution of patent deposits, applicant of patents by country, distribution of patents according to International Patent Classification codes, and the types of patented products. E United States Patent and Trademark Office (USPTO) and World Intellectual Property Organization (WIPO) were the banks with the largest number of patents for products/formulations with C. sinensis for oral care applications with 7 (35%) and 6 (30%) patent registrations, respectively. E study pointed out a small number of products protected by patents for Camellia sinensis for oral care indication, highlighting mainly mouthwash compositions and formulations. Among the most varied types of teas, Camellia sinensis (C. sinensis) teas stand out as one of the most popular and used worldwide [5,6,7]
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