Abstract
The effects of five protoberberine alkaloids (PBAs) from rhizoma of Coptis chinensis Franch on Staphylococcus aureus growth were investigated by calorimetry. The power-time curves of S. aureus with and without PBA were measured in closed glass ampoules in a TAM Air isothermal calorimeter. And, the extent and duration of inhibitory effects on the metabolism were evaluated by growth rate constant ( k), half inhibitory ratio (IC 50), maximum heat-output ( P max) and peak time ( t p). The obtained calorimetric data showed that the inhibitory action varied for different protoberberine alkaloid. The results also revealed that the sequence of antimicrobial activity of five PBAs was: berberine>coptisine>palmatine>epiberberine>jatrorrhizine. One explanation could be substitutions at several positions in the core structure of berberine possess different antimicrobial activity. In conclusion, it can be proposed that this technique should be as a useful analytical method for determining the bioactivity of PBAs.
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