Abstract
The heat production of human granulocytes activated with phorbol-12-myristate-13-acetate was determined in the absence and presence of erythrocytes. The heat produced by the erythrocytes agreed with the enthalpy change calculated, assuming that glucose oxidation had occurred. Reaction of the heme with CO almost completely prevented the metabolic response of the erythrocytes. The primary site of the metabolic activation for the erythrocytes in response to oxidant stress, exerted by the toxic granulocyte metabolites, is presumed to be the heme group. The data obtained demonstrate that significant metabolic interactions occur between activated granulocytes and erythrocytes. The power evolution observed is explained in terms of glucose combustion.
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