Abstract

Weight loss is inherently linked to the utilization of stored fats and should be detectable as changes in the blood lipidome. Such lipid changes may serve as biomarkers and may reveal protective responses, eg, in markers associated with insulin resistance or risk of type II diabetes. Conversely, fat utilization may be biased, at least initially, towards the metabolism of unsaturated fats vs saturated fats, which could have important public health consequences, as acute weight‐loss might be a period of exposure conditions that favor atherosclerosis development.Testing these issues in FBNF1 rat models of both stable and acute weight loss/caloric restriction (CR) enabled control of diet quantity/quality and minimized confounds. Rats were fed ad libitum, different periods of 40% CR (1, 2, 4, 8, or 18 weeks), or 10–40% CR for 8 weeks. Sera lipids were assessed using a high resolution mass spectrometry‐based analysis that detected >;500 intact lipids (>;300 structurally identified), spanning 6 LIPIDMAPS categories. Data supporting both issues above were observed. Data are also compared with metabolomics biomarkers for: (i) CR defined in rats that cross‐species to reflect caloric intake and future disease risk in humans, and; (ii) relative intakes and quality of dietary protein, carbohydrate, and fat. Complementary analyses are in progress in the NIA CALERIE trial of CR in humans. NIH support

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call

Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.