Abstract
We have previously demonstrated that short-term (for 4 weeks) caloric restriction (CR) improved ischemic tolerance in both young and aged rat hearts independent of opening of KATP channels (JMCC 2005;39:285–96). In addition, we proposed an obligatory role of adiponectin-AMP-activated protein kinase (AMPK) signaling on CR-induced cardioprotection. Thus, we investigated the effect of prolonged CR on ischemic tolerance and whether the mechanism(s) whereby prolonged CR protected myocardium against ischemia (I) /reperfusion (R) injury was the same as in short-term CR.
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