Abstract
Biomagnetic field measurement is a promising tool for the investigation of electrical activities in a living body. Room temperature (RT) magnetic sensors with an improved resolution such as magnetoresistance (MR) devices have been recently employed for the detection of weak magnetic fields, which were earlier detected solely using superconducting interference device magnetic sensors. The position, orientation, and sensitivity of each magnetic sensor in a sensor array must be precisely determined for accurate magnetic source analysis. We proposed a calibration method using an array of multiple coils, which is applicable to an RT magnetic sensor array. To demonstrate the validity of the proposed calibration method, we applied it to an MR device-based magnetocardiography (MCG) system equipped with an L-shaped planar sensor array, which was newly developed for the simultaneous observation of both anterior and lateral sides of the body. The deviation of the sensor parameters from the designed values was estimated via calibration. The result of the marker coil localization test indicated that the calibration considerably improved the accuracy of the magnetic source analysis. Finally, we demonstrated a preliminary MCG measurement using the calibrated magnetic sensor array.
Highlights
B IOMAGNETIC field measurement is a promising tool for the noninvasive investigation of electrical activities in a living body
We propose a calibration method using an array of multiple coils that is applicable to room temperature (RT) magnetic sensor arrays as well as superconducting quantum interference devices (SQUIDs) magnetic sensor arrays and demonstrate that the calibration of the sensor array improves the accuracy of the magnetic source analysis with a newly developed RT-magnetic-sensor-based MCG system
We proposed a method for the calibration of RT magnetic sensor arrays to obtain the effective position, orientation, and sensitivity of each magnetic sensor using an array of multiple coils and parameter optimization via a numerical search
Summary
B IOMAGNETIC field measurement is a promising tool for the noninvasive investigation of electrical activities in a living body. The electrical activities of neurons or muscles induce weak magnetic fields that can be detected using highly sensitive magnetic sensors arranged along the body surface. Superconducting quantum interference devices (SQUIDs) have been employed for detecting biomagnetic signals so far [1]. Room temperature (RT) magnetic sensors with an improved resolution such as fluxgate or magnetoresistance (MR) devices have been employed for the detection of weak biomagnetic fields. RT magnetic sensors have a significant advantage over the SQUID magnetic sensors in terms of flexibility in sensor arrangement. As a cryostat is not necessary for RT magnetic sensors in contrast to the SQUID magnetic sensors, RT magnetic sensors can be positioned closer to the magnetic source and larger magnetic signals can be obtained. The RT magnetic sensors can be arranged over a wider observation area because the size of the sensor array is not limited by the size of the cryostat
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