Abstract
Biological dosimetry aims to estimate individual absorbed doses due ionizing radiation exposure. The dicentric chromosomes are considered the most specific biomarker for dose estimation. This study aimed to compare calibration curves for linear low energy transfer (LET) radiation built from low dose rates and whether they vary in terms of dose estimation. For that we did a search in the literature of all calibration curves produced with low dose rates and we simulated the dose estimation from pre-established dicentric’s frequencies. The information on methodologies and cytogenetic results of each study were analyzed. As expected dose rate influence β coefficients, especially at higher doses. However, we have seen that some doses were not statistically different but they should be, because there is a significant association between the productions of dicentrics and dose rate. This comparative study reinforced the robustness of the dicentric assay and its importance in biological dosimetry. We also emphasized that the dose rate was an important factor in dose estimations. Thus, intercomparison exercises should take into account the dose rates of the participating laboratories, because the dose rates might explain why some results of estimated doses fall outside the recommendations.
Highlights
Biological dosimetry aims to estimate individual absorbed doses due ionizing radiation exposure
This study aimed to compare calibration curves for linear low energy transfer (LET) radiation built from low dose rates and whether they vary in terms of dose estimation
The distributions of dicentric cells selected for our calibration curve followed a Poisson distribution (Table 1), and the curve was adjusted to linear-quadratic model (Table 2) as expected for blood samples homogeneously exposed to low LET gamma-radiation (IAEA, 2011)
Summary
Biological dosimetry aims to estimate individual absorbed doses due ionizing radiation exposure. Adequate dose estimation is based on biomarkers analysis that should be specific and sensitive to radiation, and independent of other environmental exposures. Dicentrics can be used to individual dose assessment for homogeneous whole-body exposures to doses as low as 100 mGy for low linear energy transfer (LET) radiation, if up to 1000 cells are analyzed. It is possible differentiates between partial and whole body exposures, as Recife, PE, Brazil
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