Abstract
Background Peripheral arterial disease (PAD) is associated with impaired function of the lower extremities, manifested clinically as intermittent claudication or rest pain. Previous studies have suggested that alterations in microcirculation due to a paucity of collateralization may contribute to functional impairment in PAD patients. Therefore, small vessel blood flow at the level of leg muscles may be important. We hypothesized that microvascular perfusion can be measured with CE-MRI and will be heterogeneous in calf muscles of PAD patients compared with healthy controls. Methods
Highlights
Peripheral arterial disease (PAD) is associated with impaired function of the lower extremities, manifested clinically as intermittent claudication or rest pain
We hypothesized that microvascular perfusion can be measured with contrastenhanced magnetic resonance imaging (CE-MRI) and will be heterogeneous in calf muscles of PAD patients compared with healthy controls
The Microvascular perfusion maps (MVPM) categorized each voxel as either hypointense (voxel signal intensity (SI) < reference SI 2*standard deviation [STD]), isointense, or hyperintense, based on reference signal intensities for each muscle group that were calculated from all controls using an ensemble means algorithm
Summary
Calf muscle perfusion maps from contrastenhanced magnetic resonance imaging (CE-MRI) to assess peripheral arterial disease. Gerd Brunner1*, Jean Bismuth, Vijay Nambi, Christie M Ballantyne, William Zoghbi, Alan Lumsden, Joel D Morrisett, Dipan J Shah. From 17th Annual SCMR Scientific Sessions New Orleans, LA, USA. From 17th Annual SCMR Scientific Sessions New Orleans, LA, USA. 16-19 January 2014
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
