Calculating the Delta Entropy of Differentiation Module in Different Paediatric Sepsis via Analysis of Gene Network

Abstract

Paediatric sepsis refers to the body reaction disorder caused by the infection of blood by pathogens. In this study, the researchers aimed to differentiate the 5 types of paediatric sepsis by integrating the mRNA data and PINs analysis. Twenty-three SIRS, 24 uncomplicated sepsis, 21 severe sepsis, 33 septic shock and 28 sepsis deaths were enrolled. The potential genes related to paediatric sepsis were explored. The researchers found that the nodes of SIRS modules were 8, 7 and 4 with corresponding edges of 28, 21 and 6. The nodes of uncomplicated sepsis were 6, 3 and 5, with corresponding edges of 15, 3 and 10. The nodes of severe sepsis module and corresponding edges respectively were 3 and 3. One differentiation module of sepsis death contained 4 nodes and 6 edges. In conclusion, the genes that participate in the ribosome and cell cycle pathways probably play important roles in the development of paediatric sepsis.