Abstract
Background: Fatty acid binding protein 4 (FABP4) is a predominantly cytosolic protein of adipocytes, but also abundantly present in human plasma; its plasma concentrations were linked to obesity and metabolic syndrome. Recent studies have suggested a direct extracellular effect of FABP4 in the regulation of glucose metabolism and heart function independently of its effect as a carrier protein. Interestingly, FABP4 has no secretory signal sequence, so that the mechanisms how FABP4 is released from adipocytes are unclear.
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