Abstract
Calcium ions caused a marked increase in the level of endogenous phosphorylation of specific proteins from highly purified synaptic vesicle fractions. The calcium-dependent phosphorylation of two synaptic vesicle proteins was inhibited by phenytoin. The effects of calcium and phenytoin were independent of ATP concentration. The results are compatible with the hypothesis that the effects of calcium ions on the level of phosphorylation of specific synaptic vesicle-associated proteins may be the underlying molecular mechanism mediating some of the effects of calcium on neurotransmitter release and synaptic vesicle function.
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