Abstract
Publisher Summary This chapter discusses the calcium-dependent anion secretion in endometrial epithelial cells. The endometrial epithelium is similar to secretory epithelia in the lung and gastrointestinal tractm, where signaling molecules that increase intracellular cAMP or calcium will elicit anion secretion. Little is known about calcium-activated chloride channels in endometrial epithelial cells. However, the emerging data from the mouse and porcine endometrium demonstrates the existence and physiological role of calcium-activated chloride channels in calcium-dependent anion secretion. In porcine endometrial cells, attempts at a molecular characterization of the channel indicate that it is distinct from previously characterized (CLCA) channels and may represent either a new member of the existing CLCA family or perhaps a new family of Ca 2+ -activated chloride channels. In any case, the importance of its role in anion secretion in the endometrium is evident. Data from porcine endometrial epithelial cells suggest that mobilization of intracellular calcium is responsible for activating an apical Ca 2+ -activated chloride channel and basolateral K + channels, which are essential for anion secretion. Anion secretion, along with the coupled paracellular movement of Na + ions, sets up an osmotic driving force for the movement of fluid into the glandular lumen.
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