Abstract
Myeloperoxidase and lactoperoxidase are important enzymes in the microbicidal defense of the host Myeloperoxidase, involved in the microbicidal and inflammatory action of neutrophils, catalyzes the formation of hypochlorous acid from hydrogen peroxide and chloride ion. Hypochlorous acid causes rapid degradation of biological compounds and may be the ultimate toxin in the neutrophil antimicrobial system. Myeloperoxidase is a tetrameric 150 kDa enzyme consisting of two light chains (Mr 15 kDa) and two heavy chains (Mr 60 kDa); each heavy chain has a single iron prosthetic group (Andrews and Krinsky 1981). Lactoperoxidase, an enzyme found in milk, catalyzes the oxidation of thiocyanate in the presence of peroxide. The enzyme consists of a single polypeptide chain of unknown sequence with Mr 78.5 kDa, 10% carbohydrate content and one heme prosthetic group (Paul and Ohlsson 1985).
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