Abstract
1. 1. Cardiac function of STZ-diabetic rats has been shown to be partially improved by myo-inositol treatment. We studied the effect of myo-inositol on Ca 2+-uptake activity in sarcoplasmic reticulum in diabetic animals. 2. 2. Cardiac sarcoplasmic reticulum Ca 2+-uptake activity was significantly depressed in 8-week diabetic rats. 3. 3. Myo-inositol treatment could not improve Ca 2+-uptake activity in diabetic rats. 4. 4. The data suggest that the cardiac dysfunction in diabetic rats is due to factors other than the decreased Ca 2+-uptake activity in sarcoplasmic reticulum.
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