Abstract
The uptake and the rate of equilibration of subcutaneously administered Ca45in submaxillary glands of rats are increased by the administration of pilocarpine. Both effects are readily blocked by the administration of atropine. Quantitatively similar effects can also be induced in isolated whole lacrimal glands, in which both the uptake and loss of Ca45are increased by parasympathetic stimulants. In contrast to these enhancing effects of parasympathetic stimulants on Ca45transfer, the uptake of K42after subcutaneous administration and the distribution of intravenous K42to submaxillary gland, as compared to kidney, are not changed by the administration of pilocarpine. This lack of an effect on K42distribution probably reflects a lack of effect on the blood flow through the gland. Thus, the increase in uptake of Ca45produced by pilocarpine probably indicates an effect on some specific cellular mechanism by which calcium enters the gland, since many other substances have not been affected comparably. These include P32, Na22, 1131, Sr85, α-aminoisobutyric acid-C14, and glucose-C14.
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