Calcium sulfate barrier for regeneration of human bone defects. 3 years randomized controlled study

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Several experimental studies have been performed in order to evaluate the behavior of different types of biomaterials involved in the process of tissue and bone regeneration. The guided bone regeneration (GBR) principles are applied in the rebuilding of periodontal tissues, damaged by the periodontal inflammatory process. Since the introduction of GBR biological principles, a wide range of materials have been tested and used as a physical barrier. At present, the autogenous material continues to be considered the best choice when reconstruction of bone defects is intended. Calcium phosphate ceramics have been widely applied as bone substitutes, coatings, cements, drug delivery systems and tissue engineering scaffolds due to their resemblance to the mineral portion of the bone tissue, relative ease in processing and good cell attachment. 40 patients (25 males and 15 females) planned to receive bone regeneration procedure were included in the study. 20 patients were treated for bone regeneration using just BondBone, 10 patients using BondBone and a Collagen membrane and the remaining 10 patients with Bone substitute and a collagen membrane. This study has evaluates the bone tissue behavior of calcium sulfate barrier in bone repair in human bone, observing the GBR biological principles. We can conlude that calcium sulfate can work as a completion material, space maintainer, vehicle for a controlled release of certain drugs, associated with other graft materials.