Abstract
Heart failure with preserved ejection fraction (HFpEF) accounts for half of all cases of heart failure. It is defined by impaired cardiac filling in the setting of a normal ejection fraction. Up to 50 % of HFpEF mortality is due to sudden cardiac death. The underlying arrhythmogenic mechanisms are unknown and treatment options are limited. We used a recently developed “two-hit” model of HFpEF in C57BL/6 mice which are subjected to simultaneous metabolic and hypertensive stressors. Diastolic dysfunction and preserved systolic function were confirmed using speckle-tracking echocardiography for global strain analysis of myocardial function.
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