Abstract
An important trigger of hormone secretion from pituitary cells is a rise in cytosolic Ca 2+ ([Ca 2+] i). Pituitary cells may modulate [Ca 2+] i by an increased membrane flux from the extracellular space and/or by a release from intracellular stores. Both mechanisms can support exocytosis, although in different pituitary cell types one or the other mechanism may predominate. Molecular events transducing a rise in [Ca 2+] i into hormone secretion are still poorly understood. Here, the exocytotic machinery in pituitary cells is briefly reviewed in terms of the spatial organization of [Ca 2+] i elevation relative to the Ca 2+ sensor(s).
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