Abstract
Background/Aim: Genetic factors have been implicated in the pathogenesis of osteoporosis, a common disorder in primary biliary cirrhosis (PBC) and decreased bone mineral density (BMD) with elevated serum osteoprotegerin and beta-cross-laps was described by our group in Wilson disease (WD). The CaSR “A986S“ genotype was shown to affect serum Ca2+ levels, and an association between the polymorphism and BMD was reported. Our aim was to investigate the A986S CaSR polymorphism and BMD in Hungarian PBC and WD patients.
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